CLINICAL MEDICINE

Detailed explanation-1: -The correct answer is Digoxin. Generally, cardiac glycosides are selective inhibitors of the sodium-potassium ATPase pump. The digoxin, Cardizem, and Protonix are the drugs useful in the inhibition of sodium-potassium ATPase pumps.

Detailed explanation-2: -Digitalis drugs, useful for the treatment of heart failure and atrial arrhythmias, inhibit the pumping function of Na/K‐ATPase and stimulate its signaling function.

Detailed explanation-3: -The mechanism by which digitalis inhibits the sodium pump has been established in studies of Na+-K+ ATPase which show that the ability of cardiac glycosides to inhibit adenosine triphosphate (ATP)-supported transport of Na+ is reduced in the presence of elevated levels of K+.

Detailed explanation-4: -Digoxin blocks the sodium/potassium ATPase pump. The mechanism by which this decreases AV conduction is not clear but is perhaps due to increased vagal tone. Intracellular calcium within the cardiac myocytes is increased by digoxin, resulting in increased inotropy, or contractility.

Detailed explanation-5: -Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations.