CLINICAL MEDICINE

Detailed explanation-1: -Negative Feedback Mechanism It occurs when the original effect of the stimulus is reduced by the output. Negative feedback mechanism normalizes the things when they start becoming too extreme. For eg., the thyroid gland is regulated by a negative feedback mechanism.

Detailed explanation-2: -negative feedback: A feedback loop in which the output of a system reduces the activity that causes that output.

Detailed explanation-3: -Negative feedback (or balancing feedback) occurs when some function of the output of a system, process, or mechanism is fed back in a manner that tends to reduce the fluctuations in the output, whether caused by changes in the input or by other disturbances.

Detailed explanation-4: -If the determination is that the stimulus differs from the setpoint, it generates a response and sent to the effector organ. A system that utilizes these components is known as a negative feedback system, although the opposite is not true: negative feedback does not mean the system is homeostatic in function.[5]