CLINICAL MEDICINE

Detailed explanation-1: -Organification is a biochemical process that takes place in thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO).

Detailed explanation-2: -Iodide oxidation and organification occur mainly in the thyrocyte apical surface and these reactions are catalyzed by thyroperoxidase (TPO) in the presence of hydrogen peroxide.

Detailed explanation-3: -Iodination of tyrosine residues in thyroglobulin is a key step in thyroid hormone biosynthesis. In one sense, therefore, it is not surprising that excess iodine can lead to increased thyroid hormone production. However, there are mechanisms to control thyroid hormone overproduction in these situations.

Detailed explanation-4: -Organification: TPO links tyrosine residues of thyroglobulin protein with I2. It generates monoiodotyrosine (MIT) and diiodotyrosine (DIT).