CLINICAL MEDICINE

Detailed explanation-1: -These thyroid follicles act as storage compartments filled with a substance called the colloid. This colloid is thyroglobulin, which is nothing but acidophilic secretory glycoprotein that is PAS-positive.

Detailed explanation-2: -Thyroglobulin is an essential substrate for organification and is the major protein component of the colloid in the thyroid follicular lumen. It is an iodinated glycoprotein with a molecular weight approximating 650, 000 daltons. It consists of two monomeric chains, each with 67 tyrosine residues.

Detailed explanation-3: -Thyroglobulin is the most abundant protein in the thyroid gland, and the protein backbone for synthesis of T3 and T4 hormones. The most stable form of Tg is a 660 kDa glycoprotein built of two chains (12S forms), 330 kDa each [68].

Detailed explanation-4: -building hormones Thyroglobulin is stored within the gland in follicles as the main component of a substance called the thyroid colloid. This arrangement, which provides a reserve of thyroid hormones, perhaps reflects the frequent scarcity of environmental iodine, particularly on land and in fresh water.