MEDICINE
HAEMATOLOGY
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
Lymphoblastic Cells
|
|
|
Mature Cells
|
|
|
Normal Cells
|
|
|
None of the above
|
Detailed explanation-1: -Terminal deoxynucleotidyl transferase (TdT)-negative T-cell lymphoblastic lymphoma is a variant of T-cell lymphoblastic lymphoma/T-cell lymphoblastic leukaemia. TdT is a marker of immaturity expressed in 90%-95% cases of lymphoblastic lymphoma and useful in differentiating it from other mature lymphomas/leukaemias.
Detailed explanation-2: -Terminal deoxynucleotidyl transferase (TdT) is a biochemical marker for acute lymphoblastic leukemia (ALL). In studies of ALL at diagnosis, there are usually greater than 40% TdT-positive cells by indirect immuno-fluorescence, whereas acute myeloblastic leukemia (AML) shows less than 1% TdT-positive cells.
Detailed explanation-3: -Markers such as CD10, CD19, CD20, CD21, CD22, CD23, CD24, and HLA-DR are commonly used to characterize B-ALL. However, one must be cautious in use of these markers, because no marker is absolutely lineage specific and stage specific.