CLINICAL MEDICINE

MEDICINE

HAEMATOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following correctly illustrates the maturation phases of a neutrophil?
A
Blast > Promyelocyte > Metamyelocyte > Myelocyte > Band Neutrophil > Segmented Neutrophil
B
Blast > Promyelocyte > Segmented Neutrophil > Myelocyte > Band Neutrophil > Metamyelocyte
C
Promyelocyte > Blast > Myelocyte > Metamyelocyte > Band Neutrophil > Segmented Neutrophil
D
Blast > Promyelocyte > Myelocyte > Metamyelocyte > Band Neutrophil > Segmented Neutrophil
Explanation: 

Detailed explanation-1: -The cells represented six different stages of granulocytic maturation: myeloblast, promyelocyte, myelocyte, metamyelocyte, band form, and polymorphonuclear granulocyte.

Detailed explanation-2: -Metamyelocytes, together with myelocytes and promyelocytes, are precursors of neutrophils, the largest class of white blood cell. These immature neutrophils are normally found only in the bone marrow. In the blood, it is metamyelocytes that are the most often observed, accompanied by a few myelocytes.

Detailed explanation-3: -Early granulocyte precursors (myeloblast and promyelocyte) appear similar between the various granulocytic cell lines until the myelocyte stage, which is the final stage capable of cell division. At this stage, they develop characteristic secondary lineage-specific granules (neutrophilic, eosinophilic or basophilic).

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