EDUCATION (CBSE/UGC NET)

Detailed explanation-1: -Thirst is a biological instinct, mediated by sensory receptors called osmoreceptors. These receptors are located in the hypothalamus and detect changes in blood plasma. When they detect low blood volume, they signal to the hypothalamus which in turn generates the sensation of thirst.

Detailed explanation-2: -The primary osmoreceptors that control AVP secretion and thirst are located in the anterior hypothalamus, and lesions of this region in animals cause hyperosmolality through a combination of impaired thirst and osmotically stimulated AVP secretion.

Detailed explanation-3: -The osmoreceptors have a defined functionality as neurons that are endowed with the ability to detect extracellular fluid osmolarity. Osmoreceptors have aquaporin 4 proteins spanning through their plasma membranes in which water can diffuse, from an area of high to low water concentration.

Detailed explanation-4: -When the osmoreceptors in the hypothalamus detect an increase in the concentration of blood plasma, the hypothalamus signals the release of ADH from the posterior pituitary into the blood.