OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Macrophages
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Lymphocytes
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CD4 cells
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APCs
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Detailed explanation-1: -A monokine is a cytokine produced by monocytes and macrophages that has a regulatory effect on the function of other cells such as lymphocytes. Monokines include interleukin-1, tumor necrosis factor (TNF), and interferons and colony-stimulating factors.
Detailed explanation-2: -Monokines are cytokines produced mainly by monocytes and macrophages for function in the immune system. Monokines can function as chemoattractants for guiding neutrophil migration.
Detailed explanation-3: -M1 macrophages are characterized by an elevated ability to secrete cytokines such as IL-1, TNF, IL-12, and IL-18; phenotypically, they express high levels of main histocompatibility complex class II (MHC-II), CD68 marker, and CD80 and CD86 costimulatory molecules.