MUSCLE PHYSIOLOGY

Detailed explanation-1: -During development of skeletal muscle tissue, myoblasts differentiate and fuse together to form multinucleated myofibers, which are analogous to myotubes in vitro. After myofiber formation during embryogenesis, the size of individual myofibers greatly increases during the immediate postnatal period.

Detailed explanation-2: -Multinucleation is one mechanism adopted by cells to generate and sustain large cell sizes. Muscle cells are one of the largest cell types, which are formed by fusion of mononucleated myoblasts and contain up to several tens (invertebrates) to several hundred (vertebrates) nuclei.

Detailed explanation-3: -Many types of large cells have multiple nuclei. In skeletal muscle fibers, the nuclei are distributed along the cell to maximize their internuclear distances. This myonuclear positioning is crucial for cell function.