MUSCLE PHYSIOLOGY

Detailed explanation-1: -Duchenne Muscular Dystrophy (DMD) is an X-linked recessive neuromuscular disease. This fatal disease affects approximately 1:3, 500 to 6, 000 live male births [1] and 1:50, 000, 000 live female births [2], [3].

Detailed explanation-2: -Duchenne muscular dystrophy is often only associated with people assigned male at birth, as it is caused by a mutation on a gene located on X chromosomes and so in people with XY chromosomes there is no other functioning gene to compensate.

Detailed explanation-3: -It affects boys more often than girls. Girls can carry the gene that causes Duchenne, but usually have only mild symptoms. Boys usually begin to have problems by age 3–5, when muscle weakness affects walking, climbing steps, and other activities. Most boys will need to use a wheelchair by age 12.