MUSCLE PHYSIOLOGY

Detailed explanation-1: -A sarcomere extends from one Z disc to the successive Z disc. The Z disc serves to anchor the thin filaments to adjacent sarcomeres. Myofilaments occupy three-dimensional space. The arrangement of the myofilaments at different points in the sarcomere is shown in Figure 2-5, D and F.

Detailed explanation-2: -Figure 10.2. 3 – The Sarcomere: The sarcomere, the region from one Z-disc to the next Z-disc, is the functional unit of a skeletal muscle fiber.

Detailed explanation-3: -Z-discs serve three main functions in the sarcomere: (1) stabilizing F-actin filament structures, (2) allowing force transfer between individual sarcomeres, and (3) acting as signaling centers communicating with the nucleus (Clark et al., 2002; Knoll et al., 2011; Sanger and Sanger, 2008).

Detailed explanation-4: -Myosin filaments extend throughout the A-band and are thought to overlap in the M-band. The giant protein titin (connectin) extends from the Z-line of the sarcomere, where it binds to the thin filament system, to the M-band, where it is thought to interact with the thick filaments.