MUSCLE PHYSIOLOGY

Detailed explanation-1: -ACh binds to receptors on the sarcolemma known as nicotinic acetylcholine receptors (nAChRs). This binding allows the flow of sodium down its concentration gradient creating an action potential leading to depolarization of the muscle fiber.

Detailed explanation-2: -The release of acetylcholine occurs when an action potential is relayed and reaches the axon terminus in which depolarization causes voltage-gated calcium channels to open and conduct an influx of calcium, which will allow the vesicles containing acetylcholine for release into the synaptic cleft.

Detailed explanation-3: -Acetylcholine Receptors Upon binding acetylcholine, this ligand-gated ion channel depolarizes the sarcolemma and triggers muscle contraction, so it is important to regulate AChR activity and location.