PHYSIOLOGY
MUSCLE CONTRACTION
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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After calcium is released from the SR, it binds to ____
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troponin
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tropomyosin
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actin
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myosin
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Explanation:
Detailed explanation-1: -(2) Calcium binds to troponin C, which induces a conformational change in the troponin complex. This causes tropomyosin to move deeper into the actin groove, revealing the myosin-binding sites.
Detailed explanation-2: -The calcium ions released from endoplasmic reticulum72) bind to the calcium-binding subunit of troponin (troponin-C (TnC), ∼18 kDa), and the inhibition by troponin is neutralized to trigger muscle contraction.
Detailed explanation-3: -Ca2+ ions trigger muscle contraction and the release of Ca2+ from the sarcoplasmic reticulum (the intracellular Ca2+ storage site) plays an important role in determining the intramuscular Ca2+ concentration.
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