PHYSIOLOGY
MUSCLE CONTRACTION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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After the muscle is no longer stimulated, what occurs first
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Acetylcholinesterase is released and removes ACh
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The muscle continues to contract for a few more minutes
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Enzymes break down calcium ions
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The ion channels pump sodium back out of the cell and potassium back into the cell
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Explanation:
Detailed explanation-1: -Many toxins can affect neuromuscular junctions and their nicotinic receptors. Some toxins, such as the botulin toxin, act on the presynaptic side of the junction. They prevent it from releasing acetylcholine and thus produce an effect of muscle weakness or paralysis.
Detailed explanation-2: -Inhibition of AChE in muscarinic synapses (neuromuscular system) induces cholinergic crisis. Nicotinic synapses (central nervous system, e.g. brain) are also effected. Symptoms include sweating, saliva-tion, miosis (pinpoint pupils), pa-ralysis, respiratory failure, seizures and eventually death.
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