MUSCLE PHYSIOLOGY

Detailed explanation-1: -The release of acetylcholine occurs when an action potential is relayed and reaches the axon terminus in which depolarization causes voltage-gated calcium channels to open and conduct an influx of calcium, which will allow the vesicles containing acetylcholine for release into the synaptic cleft.

Detailed explanation-2: -Extracellular calcium ions enter the axon terminal via the voltage-gated calcium channels. These calcium ions then attach to the vesicles that contain ACh. The attachment of the calcium ions to the vesicles causes the release of ACh in the synaptic cleft.

Detailed explanation-3: -Low concentrations of the native agonist, acetylcholine, induce repetitive calcium spikes in the neurons characteristic of muscarinic receptors, while higher concentrations induce nonoscillating increases in intracellular calcium that include contributions from nicotinic receptors.

Detailed explanation-4: -How does acetylcholine (ACh) work? Acetylcholine is stored at the end of nerve cells until it’s triggered to be released. Once released from the end of the nerve cell, it moves into a space called the synaptic cleft.