PHYSIOLOGY
MUSCLE CONTRACTION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Once the action potential reaches the end of the axon terminal what takes place?
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ACh is released into the synaptic cleft.
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Calcium is pumped into the sarcolemma.
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Calcium is pumped into the AT.
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The muscle contracts.
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Explanation:
Detailed explanation-1: -When the action potential reaches the terminal, it activates voltage-dependent calcium channels, allowing calcium ions to flow into theterminal. In the resting state, neurotransmitters are stored in vesicles at the pre-synaptic terminal.
Detailed explanation-2: -Upon entering a presynaptic terminal, an action potential opens Ca2+ channels, and transiently increases the local Ca2+ concentration at the presynaptic active zone. Ca2+ then triggers neurotransmitter release within a few hundred microseconds by activating synaptotagmins Ca2+.
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