PHYSIOLOGY
MUSCLE CONTRACTION
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Question
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Prevents actin-myosin interaction
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ATP
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Nebulin
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Tropomyosin
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F-actin
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Explanation:
Detailed explanation-1: -1 Tropomyosin. TM regulates smooth muscle contraction by blocking the myosin binding sites on actin, preventing actin–myosin interaction. Phosphorylated HSP27 aids in the exposure of the myosin binding sites on actin for actin–myosin interaction by stabilizing the displaced TM on actin during contraction.
Detailed explanation-2: -Cooperative activation of actin-myosin interaction by tropomyosin (Tm) is central to regulation of contraction in muscle cells and cellular and intracellular movements in nonmuscle cells. The steric blocking model of muscle regulation proposed 40 y ago has been substantiated at both the kinetic and structural levels.
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