MUSCLE PHYSIOLOGY

Detailed explanation-1: -Sarcomeric myosin has the remarkable ability to form highly organized bipolar thick filaments in myofibrils . Extensive biochemical studies have demonstrated that thick filament formation is mediated by the distribution of charge along LMM (Atkinson & Stewart, 1991; Sohn et al., 1997).

Detailed explanation-2: -As illustrated in Figure 2-5, each sarcomere contains two types of myofilaments: thick filaments, composed primarily of the contractile protein myosin, and thin filaments, composed primarily of the contractile protein actin.

Detailed explanation-3: -In striated muscle cells, myosin forms the backbone of the thick filaments, which are anchored within the M-band and extend bidirectionally toward the two opposite ends of the sarcomere (171, 247).

Detailed explanation-4: -The thick filament, myosin, has a double-headed structure, with the heads positioned at opposite ends of the molecule. During muscle contraction, the heads of the myosin filaments attach to oppositely oriented thin filaments, actin, and pull them past one another.

Detailed explanation-5: -The thick filaments are composed of myosin with the globular heads forming cross-bridges with thin filaments.