MUSCLE PHYSIOLOGY

Detailed explanation-1: -This review discusses the role of myosin, a main component of the thick filament, in thick filament formation and the dynamics of myosin in skeletal muscle cells. Changes in the number of myofibrils in myofibers can cause muscle hypertrophy or atrophy.

Detailed explanation-2: -The thick filaments are composed strands of the protein myosin, and the thin filaments are strands of the protein actin, along with two other muscle regulatory proteins, tropomyosin and troponin.

Detailed explanation-3: -Most of the cytoplasm consists of myofibrils, which are cylindrical bundles of two types of filaments: thick filaments of myosin (about 15 nm in diameter) and thin filaments of actin (about 7 nm in diameter).

Detailed explanation-4: -An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments.