MUSCLE PHYSIOLOGY

Detailed explanation-1: -Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by progressive muscle degeneration and weakness due to the alterations of a protein called dystrophin that helps keep muscle cells intact.

Detailed explanation-2: -Absence or reduced expression of dystrophin or many of the DPC components cause the muscular dystrophies, a group of inherited diseases in which repeated bouts of muscle damage lead to atrophy and fibrosis, and eventually muscle degeneration.

Detailed explanation-3: -Duchenne muscular dystrophy is inherited in an X-linked recessive pattern. Males have only one copy of the X chromosome from their mother and one copy of the Y chromosome from their father. If their X chromosome has a DMD gene mutation, they will have Duchenne muscular dystrophy.

Detailed explanation-4: -Duchenne muscular dystrophy (DMD) is a lethal X-linked disease in humans characterized by the absence of dystrophin protein, which leads to progressive muscle weakness, respiratory insufficiency, and cardiomyopathy [1].

Detailed explanation-5: -DMD is inherited as an X-linked disease. X-linked genetic disorders are conditions caused by an abnormal gene on the X chromosome and manifest mostly in males. Females that have a defective gene present on one of their X chromosomes are carriers for that disorder.