PHYSIOLOGY
MUSCLE CONTRACTION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What does calcium bind to on the actin filament?
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myosin
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troponin
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tropomyosin
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actin
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Explanation:
Detailed explanation-1: -The calcium ions released from endoplasmic reticulum72) bind to the calcium-binding subunit of troponin (troponin-C (TnC), ∼18 kDa), and the inhibition by troponin is neutralized to trigger muscle contraction.
Detailed explanation-2: -Once intracellular calcium levels are raised, calcium binds to either troponin C on actin filaments (in striated muscle) or calmodulin (CaM), which regulates myosin filaments (in smooth muscle).
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