MUSCLE PHYSIOLOGY

Detailed explanation-1: -With the stimulation of the presynaptic terminal, acetylcholine is released from the vesicles and into the synaptic cleft, where the neurotransmitter is free to bind with receptors.

Detailed explanation-2: -Acetylcholine is a neurotransmitter contained in the vesicles of the pre-synaptic neuron. It is released into the synaptic cleft and activates nicotinic acetylcholine receptors on the motor end plate, and causes local motor end plate depolarization, also known as the end plate potential (EPP).

Detailed explanation-3: -Acetylcholine is stored in the terminal in small sacs, or vesicles. When an electrical impulse originating in the cell body travels down the axon to the terminal, it triggers the release of acetylcholine from the vesicles into the synaptic space (also called the synapse2) (Figure 5).