PHYSIOLOGY
MUSCLE CONTRACTION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Ca
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Na
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K
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N
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Detailed explanation-1: -The release of acetylcholine occurs when an action potential is relayed and reaches the axon terminus in which depolarization causes voltage-gated calcium channels to open and conduct an influx of calcium, which will allow the vesicles containing acetylcholine for release into the synaptic cleft.
Detailed explanation-2: -The acetylcholine molecules then bind to nicotinic ion-channel receptors on the muscle cell membrane, causing the ion channels to open. Sodium ions then flow into the muscle cell, initiating a sequence of steps that finally produce muscle contraction.
Detailed explanation-3: - When two molecules of acetylcholine bind a nicotinic AchR, a conformational change occurs in the receptor, resulting in the formation of an ion pore.