PHYSIOLOGY
MUSCLE CONTRACTION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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in the nucleus
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in the cytoplasm
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in the vesicles
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all are true
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Detailed explanation-1: -Acetylcholine is synthesized from choline and acetyl-coenzyme A (acetyl-CoA) in the cytoplasm of the nerve terminal through the enzyme choline acetyltransferase (ChAT).
Detailed explanation-2: -How is acetylcholine (ACh) made? An enzyme called choline acetyltransferase causes a reaction between choline and the acetyl group to create acetylcholine. It’s made at the end of nerve cells.
Detailed explanation-3: -Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In the nervous system, this enzyme is thought to exist primarily in the nerve terminal cytoplasm.
Detailed explanation-4: -Acetylcholine is synthesized in nerve terminals from acetyl coenzyme A (acetyl CoA, which is synthesized from glucose) and choline, in a reaction catalyzed by choline acetyltransferase (CAT) (Figure 6.8). The presence of CAT in a neuron is thus a strong indication that ACh is used as one of its transmitters.
Detailed explanation-5: -In addition, according to proteomic studies, mitochondria contain choline acetyltransferase [44] and, therefore, are able to locally synthesize acetylcholine.