MUSCLE PHYSIOLOGY

PHYSIOLOGY

MUSCLE CONTRACTION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which ion, when present, causes a change in conformation of tropomyosin?
A
Calcium
B
Sodium
C
Potassium
D
Lithium
Explanation: 

Detailed explanation-1: -calcium ions bind to troponin, causing conformational changes in troponin that allow tropomyosin to move away from the myosin-binding sites on actin.

Detailed explanation-2: -Troponin binds to tropomyosin and helps to position it on the actin molecule; it also binds calcium ions.

Detailed explanation-3: -Troponin is shown in red (subunits not distinguished). Upon binding calcium, troponin moves tropomyosin away from the myosin-binding sites on actin (bottom), effectively unblocking it.

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