MUSCLE PHYSIOLOGY

PHYSIOLOGY

MUSCLE CONTRACTION

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

Which thin filament protein bind to Ca during muscle contraction?

A	Actin
B	Myosin
C	Troponin
D	Tropomyosin

Explanation:

Detailed explanation-1: -Troponin plays a central role in the calcium-regulation of muscle contraction: Troponin is the sole calcium-binding component of thin filaments (actin-tropomyosin-troponin complex) of striated muscles.

Detailed explanation-2: -(1) Calcium binds to troponin C, causing the conformational shift in tropomyosin that reveals myosin-binding sites on actin.

Detailed explanation-3: -1: Muscle contraction: Calcium remains in the sarcoplasmic reticulum until released by a stimulus. Calcium then binds to troponin, causing the troponin to change shape and remove the tropomyosin from the binding sites.

Detailed explanation-4: -Ca2+ binding to troponin initiates thin filament activation exposing myosin binding sites on actin.

There is 1 question to complete.