MUSCLE PHYSIOLOGY

PHYSIOLOGY

MUSCLE ENERGETICS GLYCOLYSIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
During the transition step, pyruvic acid is ____ by NAD and ____ is removed to form Acetyl-CoA.
A
Oxidized, CO2
B
Reduced, CO2
C
Oxidized, O2
D
Reduced, O2
Explanation: 

Detailed explanation-1: -A carboxyl group is removed from pyruvate and released as carbon dioxide. The two-carbon molecule from the first step is oxidized, and NAD+ accepts the electrons to form NADH. The oxidized two-carbon molecule, an acetyl group, is attached to Coenzyme A to form acetyl CoA.

Detailed explanation-2: -So, the process used in conversion of pyruvate to acetyl CoA is oxidative decarboxylation.

Detailed explanation-3: -Aerobic respiration begins with the conversion of pyruvate to acetyl CoA. This conversion takes place in three steps: decarboxylation, the reduction of NAD+, and the attachment of coenzyme A.

Detailed explanation-4: -The transition reaction converts pyruvate (3 carbons) to acetyl CoA (2 carbons), producing carbon dioxide (CO2) and a NADH as shown below.

Detailed explanation-5: -Breakdown of Pyruvate Upon entering the mitochondrial matrix, a multi-enzyme complex converts pyruvate into acetyl CoA. In the process, carbon dioxide is released and one molecule of NADH is formed.

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