MUSCLE PHYSIOLOGY

Detailed explanation-1: -Glycolysis (see “Glycolysis” concept) is an anaerobic process-it does not need oxygen to proceed. This process produces a minimal amount of ATP. The Krebs cycle and electron transport do need oxygen to proceed, and in the presence of oxygen, these process produce much more ATP than glycolysis alone.

Detailed explanation-2: -Glycolysis occurs in both aerobic and anaerobic states. In aerobic conditions, pyruvate enters the citric acid cycle and undergoes oxidative phosphorylation leading to the net production of 32 ATP molecules. In anaerobic conditions, pyruvate converts to lactate through anaerobic glycolysis.

Detailed explanation-3: -Anaerobic glycolysis serves as a means of energy production in cells that cannot produce adequate energy through oxidative phosphorylation. In poorly oxygenated tissue, glycolysis produces 2 ATP by shunting pyruvate away from mitochondria and through the lactate dehydrogenase reaction.

Detailed explanation-4: -Glycolysis is the major pathway of glucose metabolism and occurs in the cytosol of all cells. It can occur aerobically or anaerobically depending on whether oxygen is available. This is clinically significant because oxidation of glucose under aerobic conditions results in 32 mol of ATP per mol of glucose.