MUSCLE PHYSIOLOGY

Detailed explanation-1: -For glycolysis, the conversion of glucose to lactate-+ H+ and the export of products into the assay medium is the source of glycolytic acidification. For respiration, the export of CO2, hydration to H2CO3 and dissociation to HCO3-+ H+ is the source of respiratory acidification.

Detailed explanation-2: -Stimulation of glycolysis accompanies a rise in pH in intact polymorphonuclear leukocytes and supernatant preparations derived from homogenates of these cells. The curve of lactate production plotted against pH for the cell-free system was steepest between pH 6.5 and 7.0.

Detailed explanation-3: -A possible explanation for the acid-induced protein catabolism and increased amino acid oxidation is that impairment of glycolysis by low pH restricts the pyruvate supply to mitochondria, leading to catabolism of amino acids from protein as an alternative metabolic fuel.

Detailed explanation-4: -The results of these studies suggest that acidosis interferes with the metabolism of glucose by inhibiting processes of phosphorylation involved in the cellular uptake of glucose; but the manner of interference is not known.