MUSCLE PHYSIOLOGY

Detailed explanation-1: -The Acetyl CoA produced enters the Tricarboxylic acid cycle or Citric acid cycle. Glucose is fully oxidized in this process. The acetyl CoA combines with 4-carbon compound oxaloacetate to form 6C citrate.

Detailed explanation-2: -The Krebs cycle itself actually begins when acetyl-CoA combines with a four-carbon molecule called OAA (oxaloacetate) (see Figure above). This produces citric acid, which has six carbonatoms. This is why the Krebs cycle is also called the citric acid cycle.

Detailed explanation-3: -Simplified diagram of the citric acid cycle. First, acetyl CoA combines with oxaloacetate, a four-carbon molecule, losing the CoA group and forming the six-carbon molecule citrate.

Detailed explanation-4: -Acetyl-CoA enters the Krebs cycle by combining with a four-carbon acid called oxaloacetic acid. The combination forms the six-carbon acid called citric acid. Citric acid undergoes a series of enzyme-catalyzed conversions. The conversions, which involve up to ten chemical reactions, are all brought about by enzymes.

Detailed explanation-5: -To start the cycle, an enzyme fuses acetyl CoA and oxaloacetate together so that citric acid is formed (a 2-carbon molecule + a 4-carbon molecule = a 6-carbon molecule!).