PHYSIOLOGY
MUSCLE ENERGETICS GLYCOLYSIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Glycolysis takes place in the cytosol.
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Glycolysis does not require a membrane which represents that it evolved prior to membrane bound organelles.
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Glycolysis has instructions in the nuclear DNA.
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Glycolysis does not require mitochondrial DNA which represents that it evolved prior to membrane bound organelles.
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Detailed explanation-1: -Glycolysis takes place in the cytoplasm. Within the mitochondrion, the citric acid cycle occurs in the mitochondrial matrix, and oxidative metabolism occurs at the internal folded mitochondrial membranes (cristae).
Detailed explanation-2: -The mitochondria simply does not contain the enzymes inside it to perform glycolysis nor does it sufficiently have the membrane transport proteins to take glucose inside. This is the simple answer.
Detailed explanation-3: -ATP Can Be Produced From Cytosolic NADH. The NADH produced in the cytosol by glycolysis cannot enter the mitochondrial matrix, yet it must be oxidized back to NAD+ to allow glycolysis to proceed.
Detailed explanation-4: -Pyruvate can be formed in the cytosol by glycolysis, or conversion from alanine by ALT, from lactate by LDH-B or from malate by malic enzyme (ME). Pyruvate crosses the outer mitochondrial membrane (OMM) probably via the VDAC into the intermembrane space (IMS). Pyruvate is then transported across the IMM by the MPC.