MUSCLE PHYSIOLOGY

PHYSIOLOGY

MUSCLE ENERGETICS GLYCOLYSIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Metabolism Problem SetProblem 12:HexokinaseIn the first step of glycolysis, the enzyme hexokinase uses ATP to transfer a phosphate to glucose to form glucose-6-phosphate. The product continues to be oxidized forming pyryvate in glycolysis and is a precursor to acetyl-CoA for the citric acid cycle. Suppose that a cell has only glucose available for energy and that the activity of hexokinase is suddenly stopped in this cell. Which of the following conditions will occur?
A
The cell will continue to produce energy from mitochondrial electron transport.
B
The cell will continue to produce ATP using the citric acid cycle.
C
The cell will ultimately be unable to produce ATP.
D
The cell will be forced to switch to fermentation to produce ATP.
Explanation: 

Detailed explanation-1: -In the first step of glycolysis, the enzyme hexokinase uses ATP to transfer a phosphate to glucose to form glucose-6-phosphate. The product continues to be oxidized forming pyryvate in glycolysis and is a precursor to acetyl-CoA for the citric acid cycle.

Detailed explanation-2: -The enzymes involved in the generation of ATP are glyceraldehyde-3-phosphate dehydrogenase (G3PD) and phosphoglycerate kinase (PGK).

Detailed explanation-3: -Glycolysis is the first step in the breakdown of glucose to extract energy for cellular metabolism. Nearly all living organisms carry out glycolysis as part of their metabolism. The process does not use oxygen and is therefore anaerobic. Glycolysis takes place in the cytoplasm of both prokaryotic and eukaryotic cells.

Detailed explanation-4: -Glycolysis is the cytosolic pathway in which one molecule of glucose is broken down into two molecules of pyruvate, along with a net production of two molecules of ATP and NADH (nicotinamide adenine dinucleotide). Pyruvates are then fully metabolized in mitochondrial respiration.

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