MUSCLE PHYSIOLOGY

Detailed explanation-1: -ethanol or lactic acid. Prior to entering the Krebs Cycle, each pyruvate molecule loses electrons, hydrogen ions, and a carbon, forming an energy-rich molecule of . . . The NADH and FADH2 that are formed in the Krebs Cycle primary function to. . . transfer electrons to the electron transport system.

Detailed explanation-2: -In order for pyruvate from glycolysis to enter the Kreb’s Cycle it must first be converted into acetyl-CoA by the pyruvate dehydrogenase complex which is an oxidative process wherein NADH and CO2 are formed. Another source of acetyl-CoA is beta oxidation of fatty acids.

Detailed explanation-3: -Pyruvate is oxidized and converted into Acetyl CoA. These two steps occur in the cytoplasm of the cell. Acetyl CoA enters into the matrix of mitochondria, where it is fully oxidized into Carbon Dioxide via the Krebs cycle.

Detailed explanation-4: -A carboxyl group is removed from pyruvate and released as carbon dioxide. The two-carbon molecule from the first step is oxidized, and NAD+ accepts the electrons to form NADH. The oxidized two-carbon molecule, an acetyl group, is attached to Coenzyme A to form acetyl CoA.