MUSCLE PHYSIOLOGY

Detailed explanation-1: -Since there are two pyruvate molecules made from each molecule of glucose, this means that the whole cycle runs two times. In the cycle, each pyruvate from glycolysis is harvested for its electrons. In the process, for every two pyruvate molecules, two ATP are produced.

Detailed explanation-2: -Within the mitochondria, each pyruvate is broken apart and combined with a coenzyme known as CoA to form a 2-carbon molecule, acetyl-CoA, which can enter the Krebs Cycle. A single atom of carbon (per pyruvate) is “lost” as carbon dioxide. The energy released in this breakdown is captured in two NADH molecules.

Detailed explanation-3: -Glycolysis, Pyruvate Oxidation and the Krebs Cycle Glycolysis, the process of splitting a six-carbon glucose molecule into two three-carbon pyruvate molecules, is linked to the Krebs cycle. For each glucose molecule respired, the cycle reactions occur twice as two pyruvic acid molecules are formed.

Detailed explanation-4: -The number of ATP molecules produced in the Krebs cycle is 2.

Detailed explanation-5: -The final step of the Krebs cycle regenerates OAA, the molecule that began the Krebs cycle. This molecule is needed for the next turn through the cycle. Two turns are needed because glycolysis produces two pyruvic acid molecules when it splits glucose.