MUSCLE PHYSIOLOGY

Detailed explanation-1: -Fructose-1, 6-bisphosphate aldolase catalyzes the conversion of fructose-1, 6-bisphosphatealdol to dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). Tagatose-1, 6-bisphosphate aldolase catalyzes the aldol condensation of DHAP with G3P to produce tagatose 1, 6-bisphosphate.

Detailed explanation-2: -Dihydroxyacetone phosphate (DHAP) is converted to glycerol-3-phosphate (G3P) by glycerol-3-phosphate dehydrogenase (GPD1) or by glycerol-3-phosphate dehydrogenase-like (GPD1L) enzymes (Ou et al. 2006, Valdivia et al. 2009). The active forms of both enzymes are homodimers.

Detailed explanation-3: -Aldolase is a cytoplasmic enzyme involved in glucose and fructose metabolism. It specifically catalyzes the reversible reaction of converting fructose 1, 6-bisphosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehydes 3-phosphate. The enzyme works on six reversible reactions in gluconeogensis and glycolysis.

Detailed explanation-4: -Dihydroxyacetone phosphate (DHAP, also glycerone phosphate in older texts) is the anion with the formula HOCH2C(O)CH2OPO32-. This anion is involved in many metabolic pathways, including the Calvin cycle in plants and glycolysis. It is the phosphate ester of dihydroxyacetone.