MUSCLE PHYSIOLOGY

Detailed explanation-1: -Adenylate kinase (AK) is a ubiquitous and abundant enzyme catalyzing the phosphoryl transfer between two adenosine diphosphate (ADP) molecules to yield adenosine triphosphate (ATP) and adenosine monophosphate (AMP).

Detailed explanation-2: -The catalytic conversion ATP + AMP → 2ADP by the enzyme adenylate kinase (ADK) involves the binding of one ATP molecule to the LID domain and one AMP molecule to the NMP domain. The latter is followed by a phosphate transfer and then the release of two ADP molecules.

Detailed explanation-3: -Adenylate kinase (Adk) is an essential housekeeping enzyme (9) that controls the energy balance in cells by catalyzing the reversible interconversion of ATP and AMP into two ADP molecules.

Detailed explanation-4: -Due to a unique property of the catalyzed reaction, adenylate kinase is recognized as a sensitive reporter of the cellular energy state, translating small changes in the balance between ATP and ADP into relatively large changes in AMP concentration [1, 2, 5, 29, 62].