MUSCLE PHYSIOLOGY

PHYSIOLOGY

MUSCLE ENERGETICS GLYCOLYSIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Where is ATP synthase located in the mitochondrion?
A
cytosol
B
electron transport chain
C
outer mitochondria membrane
D
inner mitochondria membrane
Explanation: 

Detailed explanation-1: -Human mitochondrial (mt) ATP synthase, or complex V consists of two functional domains: F1, situated in the mitochondrial matrix, and Fo, located in the inner mitochondrial membrane.

Detailed explanation-2: -The ATP synthase is a mitochondrial enzyme localized in the inner membrane, where it catalyzes the synthesis of ATP from ADP and phosphate, driven by a flux of protons across a gradient generated by electron transfer from the proton chemically positive to the negative side.

Detailed explanation-3: -In eukaryotes, the ATP synthase complex is located in the inner membrane of mitochondria, with ATP synthesis reaction occurring on the membrane side toward matrix compartment.

Detailed explanation-4: -Cardiolipin is an unusual “double” phospholipid, containing four fatty acid chains, that is found primarily in the inner mitochondrial membrane.

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