MUSCLE PHYSIOLOGY

Detailed explanation-1: -NAD+ can be reduced to NADH via dehydrogenases and can also be phosphorylated to NADP+ via NAD+ kinases (NADKs). The NAD+/NADH redox couple is known as a regulator of cellular energy metabolism, that is, of glycolysis and mitochondrial oxidative phosphorylation.

Detailed explanation-2: -Complex I (NADH dehydrogenase) is the first enzyme in the respiratory chain. It catalyses the electron transfer from NADH to ubiquinone that is associated with proton pumping out of the matrix.

Detailed explanation-3: -The enzymes using NAD+ in hydride-transfer are known as dehydrogenases or oxidoreductases, which catalyze reduction of NAD+ into NADH (Examples shown in Figure 1).