MUSCLE PHYSIOLOGY

Detailed explanation-1: -During glycolysis, glucose is broken down into two three-carbon molecules of pyruvate. The mitochondrial pyruvate dehydrogenase complex then catalyzes the oxidative decarboxylation of pyruvate to produce acetyl-CoA, a two-carbon acetyl unit that is ligated to the acyl-group carrier, CoA [6].

Detailed explanation-2: -The link reaction occurs in the mitochondrial matrix. In the first step, carbon dioxide and hydrogen are removed from two pyruvate molecules, producing two acetyl groups. The hydrogen removed is transferred to NAD, reducing it. In the second step, coenzyme A combines with the acetyl group to form acetyl CoA.

Detailed explanation-3: -The citric acid cycle captures the energy stored in the chemical bonds of acetyl CoA (processed glucose) in a step-by-step process, trapping it in the form of high-energy intermediate molecules.