MUSCLE PHYSIOLOGY

Detailed explanation-1: -In eukaryotes, the Krebs cycle reactions take place in the mitochondrial matrix, a dense solution that surrounds the mitochondria crests: in addition to water, the matrix contains all the enzymes necessary for the biochemical reactions of the cycle, coenzymes, and phosphates.

Detailed explanation-2: -In all organisms except bacteria the TCA cycle is carried out in the matrix of intracellular structures called mitochondria. The TCA cycle plays a central role in the breakdown, or catabolism, of organic fuel molecules-i.e., glucose and some other sugars, fatty acids, and some amino acids.

Detailed explanation-3: -All enzymes of the TCA cycle are located in the mitochondrial matrix except succinate dehydrogenase which is located in the inner mitochondrial membrane in eukaryotes and the cytosol in prokaryotes.

Detailed explanation-4: -Krebs cycle or TCA cycle takes place in the matrix of mitochondria under aerobic condition.

Detailed explanation-5: -The TCA cycle, also known as the citric acid cycle or the Krebs cycle, is a series of reactions in a closed loop that forms a metabolic engine within cells (Fig. 3). The TCA cycle constitutes an epicenter in cell metabolism because multiple substrates can feed into it.