PHYSIOLOGY
MUSCLE RECEPTORS
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Substantia Nigra
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Substantia Gelitanosa
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Substantia Propria
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Substantia Gracia
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Detailed explanation-1: -The pain gate mechanism is located in the dorsal horn of the spinal cord, specifically in the Substantia gelatinosa. The interneurons within the Substantia gelatinosa are what synapse to the primary afferent neurons, and are where the gate mechanism occurs.
Detailed explanation-2: -The gate control theory of pain, first proposed by Melzack and Wall in 1965, posits that the transmission of peripheral nociception from PAFs to second-order projection neurons is not automatic and instead undergoes modulation beforehand at the spinal dorsal horn.
Detailed explanation-3: -Gate control theory suggests that the spinal cord contains a neurological ‘gate’ that either blocks pain signals or allows them to continue on to the brain. This theory is often used to explain both phantom and chronic pain issues.
Detailed explanation-4: -Gate-control theory of pain According to the gate theory of pain, inhibitory interneurons regulate the transmission of ascending nociceptive information at the level of the second order neuron, allowing modulation of the signal (both increases and decreases in activity are possible).