MUSCLE PHYSIOLOGY

Detailed explanation-1: -Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers.

Detailed explanation-2: -Nociceptors are sensory receptors that detect signals from damaged tissue or the threat of damage and indirectly also respond to chemicals released from the damaged tissue.

Detailed explanation-3: -The somatosensory receptors can be activated by these different stimuli that act on mechanoreceptors (including proprioception), nociceptors, thermoreceptors and chemoreceptors.

Detailed explanation-4: -The nociceptor is characterized by its response to noxious heat, pressure, or chemical stimuli. The ‘’pain” message is coded in the pattern and frequency of impulses in the axons of the primary afferent nociceptors.

Detailed explanation-5: -Noxious cold and noxious heat stimuli are detected by A and C fiber nociceptors. The TRP channel family provides a group of molecules equipped to detect thermal changes. The full range of temperatures, from noxious cold to noxious heat, appears to be transduced by the activity in these ion channels.