MUSCLE PHYSIOLOGY

Detailed explanation-1: -Who Gets Duchenne Muscular Dystrophy? Duchenne MD affects boys more often than girls because the dystrophin gene is on the X chromosome. Boys have only one X chromosome and girls have two. So girls can almost always make working dystrophin using the dystrophin gene on their second X chromosome.

Detailed explanation-2: -Duchenne muscular dystrophy usually affects males. However, females are also affected in rare instances. Approximately 8% of female Duchenne muscular dystrophy (DMD) carriers are manifesting carriers and have muscle weakness to some extent.

Detailed explanation-3: -It affects boys more often than girls. Girls can carry the gene that causes Duchenne, but usually have only mild symptoms. Boys usually begin to have problems by age 3–5, when muscle weakness affects walking, climbing steps, and other activities. Most boys will need to use a wheelchair by age 12.

Detailed explanation-4: -Duchenne muscular dystrophy is the most common type of muscular dystrophy diagnosed in childhood. It first appears in very early childhood-only in boys-and progresses rapidly. Most children are unable to walk by age 12 and later need a respirator to breathe.

Detailed explanation-5: -Duchenne muscular dystrophy mostly affects boys and occurs in one in 3, 500 to 5, 000 newborns. There is no higher risk for any ethnic group.