PHYSIOLOGY
NEUROMUSCULAR JUNCTION TRANSMISSION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Once ACh binds to receptor cells on the sarcolemma, what happens?
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Sarcolemma becomes permeable to sodium and it enters the muscle cell.
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The muscle contracts.
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Calcium is pumped into the axon terminal.
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Synaptic vesicles move to the end of the terminal.
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Explanation:
Detailed explanation-1: -Acetylcholine release from synaptic vesicles and travels across synaptic cleft and binds with protein receptors in sarcolemma. This causes the sarcolemma to become more permeable to sodium ions which causes them enter.
Detailed explanation-2: -Acetylcholine causes f. the opening of ligand-gated cation channels. More specifically. this neurotransmitter will cause the opening of sodium channels, which will result in a large influx of sodium ions, causing a depolarization of the motor endplate, which will eventually lead to a muscle contraction.
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