MUSCLE PHYSIOLOGY

Detailed explanation-1: -Microglia account for approximately 10% of cells and are the most abundant mononuclear phagocytes in the central nervous system (CNS). During development, microglia help shape neural circuits by modulating the strength of synaptic transmissions and sculpting neuronal synapses.

Detailed explanation-2: -One part of microglia’s job is devouring the corpses of dead brain and nervous system cells via a process known as phagocytosis. Microglia (blue) are more than just a cleanup crew. They actually help maintain a healthy life cycle of neurons (green).

Detailed explanation-3: -Microglia, the resident macrophages of the central nervous system, rapidly activate in nearly all kinds of neurological diseases. These activated microglia become highly motile, secreting inflammatory cytokines, migrating to the lesion area, and phagocytosing cell debris or damaged neurons.