MUSCLE PHYSIOLOGY

PHYSIOLOGY

SKELETAL MUSCLE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What ions enter the axon terminal during action potential generation?
A
Calcium
B
Sodium
C
Potassium
D
Carbon
Explanation: 

Detailed explanation-1: -When the action potential reaches the terminal, it activates voltage-dependent calcium channels, allowing calcium ions to flow into theterminal. In the resting state, neurotransmitters are stored in vesicles at the pre-synaptic terminal.

Detailed explanation-2: -Over the course of the six experiments a total of 204/751 action potentials were prolonged. These data show that a crucial part of the calcium signal during action potential firing is generated by calcium release from intracellular stores.

Detailed explanation-3: -Typically, presynaptic terminals are enriched with the CaV2 class of calcium channels. This group is comprised of three different isoforms: CaV2.1 (P/Q-type), CaV2.2 (N-type), and CaV2.3 (R-type).

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