GENETICS AND EVOLUTION
MOLECULAR BASIS OF INHERITANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Topoisomerase
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Helicase
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RNA primase
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All of these
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Detailed explanation-1: -DNA replication requires other enzymes in addition to DNA polymerase, including DNA primase, DNA helicase, DNA ligase, and topoisomerase.
Detailed explanation-2: -The enzyme that synthesizes DNA, DNA polymerase, can only add nucleotides to an already existing strand or primer of DNA or RNA that is base paired with the template. An enzyme, DNA polymerase, is required for the covalent joining of the incoming nucleotide to the primer.
Detailed explanation-3: -The order of enzymes in DNA replication include the following: DNA helicase, RNA primase, DNA polymerase, and finally DNA ligase. During the process of DNA replication, the double helix unwinds with the help of the enzyme DNA helicase.
Detailed explanation-4: -Enzymes involved in DNA replication are: Helicase (unwinds the DNA double helix) Gyrase (relieves the buildup of torque during unwinding) Primase (lays down RNA primers)
Detailed explanation-5: -Final answer: DNA Ligase is not involved during DNA replication on the template with polarity 3’ → 5’.