NURSING ANM AND GNM

Detailed explanation-1: -Glucose 6-phosphate is dephosphorylated by glucose 6-phosphatase to form glucose, which is free to enter the bloodstream. This reaction is unique to gluconeogenesis and bypasses the irreversible reaction catalyzed by the glycolytic enzyme hexokinase.

Detailed explanation-2: -Advanced Biochemistry In the process of gluconeogenesis, there are four enzymes required to bypass the irreversible steps of glycolysis; fructose1, 6 bisphosphatase-1, Glucose 6-phosphatase, PEPCK, and pyruvate carboxylase.

Detailed explanation-3: -Glucose-6-phosphatase is a microsomal enzyme responsible for catalyzing the conversion of glucose-6-phosphate to glucose.

Detailed explanation-4: -Hexokinase converts glucose to glucose 6-phosphate, trapping the glucose molecule inside the cell, thus starting off the process of glycolysis.

Detailed explanation-5: -The classical role of glucose-6-phosphatase in liver and kidney is the production of glucose for release into blood. In liver, glucose-6-phosphatase catalyses the terminal step of glycogenolysis and gluconeogenesis.