NURSING EXAM QUESTIONS
BIOCHEMISTRY
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
DNA cannot be repaired and this explains why mutations occur.
|
|
|
Specific enzymes bind the correct nucleotides.
|
|
|
The new nucleotides basepair accurately with those on the complementary strand.
|
|
|
The repair enzyme recognizes the removed nucleotide and brings in an identical one to replace it.
|
|
|
The three-dimensional structure determines the order of nucleotides.
|
Detailed explanation-1: -Incorrectly paired nucleotides cause deformities in the secondary structure of the final DNA molecule. During mismatch repair, enzymes recognize and fix these deformities by removing the incorrectly paired nucleotide and replacing it with the correct nucleotide.
Detailed explanation-2: -Base pairing ensures that the sequence of nucleotides in the existing template strand is exactly matched to a complementary sequence in the new strand, also known as the anti-sequence of the template strand.
Detailed explanation-3: -In excision repair, the damaged DNA is recognized and removed, either as free bases or as nucleotides. The resulting gap is then filled in by synthesis of a new DNA strand, using the undamaged complementary strand as a template.
Detailed explanation-4: -Nucleotide excision repair is another pathway used to remove and replace damaged bases. Nucleotide excision repair detects and corrects types of damage that distort the DNA double helix.
Detailed explanation-5: -On a broader scale, RADAR-seq can be applied to understand formation and repair of DNA damage, the correlation between DNA damage and disease initiation and progression, and complex biological pathways, including DNA replication.