NURSING ANM AND GNM

Detailed explanation-1: -The major substrates of gluconeogenesis are lactate, glycerol, and glucogenic amino acids. Glycerol comes from adipose tissue. The breakdown of triacylglycerols in adipose tissue yields free fatty acids and glycerol molecules, the latter of which can circulate freely in the bloodstream until it reaches the liver[3].

Detailed explanation-2: -Thus, glycerol both inhibits the utilization of glucose for glycolysis and is effectively channelled into gluconeogenesis under glucose deprivation.

Detailed explanation-3: -Glycerol is a major substrate for glucose, glycogen, and nonessential amino acid synthesis in late-term chicken embryos. J Anim Sci.

Detailed explanation-4: -Both glycine and serine are glucogenic. In diabetic rats the contribution of carbon atoms from glycine to glucose increases in direct proportion to the increased glucose turnover, whereas the contribution by serine becomes also proportionally higher.